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BACKGROUND This study examined whether the magnitude of the behavioral response to repeated d-amphetamine administration previously demonstrated in a double-blind study in humans was associated with certain personality characteristics. METHODS Eleven normal volunteers completed the Tridimensional Personality Questionnaire (TPQ) prior to being administered three doses of d-amphetamine (0.25 mg/kg) alternating with three doses of placebo over 6 consecutive days. Behavioral measures included eye-blink rates as well as ratings of elevated mood, increased motor activity/energy, and increased speech. These variables were assessed once prior to dosing, then hourly for 5 hours. RESULTS A greater magnitude of change in elevated mood over the three amphetamine doses significantly correlated with ratings of the Novelty Seeking on the TPQ. CONCLUSIONS These results suggest that similar to findings in animal models, there are certain intrinsic behavioral characteristics that are associated with amphetamine sensitivity in humans.
K W Sax, and
S M Strakowski
May 1999,
Behavioural pharmacology,
K W Sax, and
S M Strakowski
May 1977,
Pharmacology, biochemistry, and behavior,
K W Sax, and
S M Strakowski
January 1975,
Advances in biochemical psychopharmacology,
K W Sax, and
S M Strakowski
November 1999,
Experimental and clinical psychopharmacology,
K W Sax, and
S M Strakowski
January 1990,
Psychopharmacology,
K W Sax, and
S M Strakowski
February 1981,
Pharmacology, biochemistry, and behavior,
K W Sax, and
S M Strakowski
March 2013,
Journal of psychopharmacology (Oxford, England),
K W Sax, and
S M Strakowski
February 1999,
Psychopharmacology,
K W Sax, and
S M Strakowski
July 1998,
Behavioural pharmacology,
K W Sax, and
S M Strakowski
August 2004,
Journal of clinical psychopharmacology,
