-transparent.png){kind=logo}
Synthesis of imidazo[1,2-a]pyridines as antiviral agents. 1998
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France.
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.
Related Publications
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
July 2004,
Journal of medicinal chemistry,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
March 1992,
Chemical & pharmaceutical bulletin,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
October 2021,
Archiv der Pharmazie,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
November 2022,
Bioorganic chemistry,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
September 1989,
Journal of medicinal chemistry,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
June 2003,
The Journal of organic chemistry,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
January 2015,
Chemical communications (Cambridge, England),
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
January 2008,
Bioorganic & medicinal chemistry,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
May 2023,
Organic letters,
A Gueiffier, and
S Mavel, and
M Lhassani, and
A Elhakmaoui, and
R Snoeck, and
G Andrei, and
O Chavignon, and
J C Teulade, and
M Witvrouw, and
J Balzarini, and
E De Clercq, and
J P Chapat
October 1987,
Journal of medicinal chemistry,
