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In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA (N-methyl-d-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of d-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial-maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801-induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors.
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
August 1999,
Brain research,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
January 2008,
Behavioural brain research,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
April 1990,
Pharmacology, biochemistry, and behavior,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
January 1998,
Brain research,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
December 2005,
Acta pharmacologica Sinica,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
September 2002,
Brain research,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
October 1993,
Behavioural pharmacology,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
October 2000,
Pharmacological research,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
January 2008,
Neurotoxicology and teratology,
K Kawabe, and
T Yoshihara, and
Y Ichitani, and
T Iwasaki
March 2002,
Life sciences,
