OBJECTIVE To discuss the presentation, treatment, and aggressiveness of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphoma and AIDS-related primary central nervous system lymphoma, and to address the differences of these lymphomas in the human immunodeficiency virus (HIV)-negative individual. METHODS Published review articles, clinical studies, and abstracts pertaining to HIV and AIDS-related lymphomas. CONCLUSIONS Many believe that as the therapies and supportive care for HIV-positive individuals improve, the incidence of malignancy in this patient population will continue to increase. Great controversy exists surrounding the most effective therapies for AIDS-related lymphomas. These patients should be entered into clinical trials to test appropriate hypotheses and answer the remaining questions. CONCLUSIONS As the HIV epidemic continues and HIV-associated malignancies increase, the nurse must understand the co-morbidity associated with both diseases. Oncology nurses play many roles in caring for this patient population and their support and intervention contribute to the response of the patient.