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Noninvasive measurement of renal function with 99mTc-MAG3 gamma-camera renography based on the one-compartment model. 1998

N Oriuchi, and Y Onishi, and H Kitamura, and T Inoue, and Y Tomaru, and T Higuchi, and T Inoue, and K Endo
Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi, Japan.

OBJECTIVE The aim of this study was to develop a method for measuring renal function with 99mTc-MAG3 gamma-camera renography without blood or urine sampling and evaluate its feasibility. METHODS Twelve patients with nephrological disorders underwent 99mTc-MAG3 renography and para-aminohippurate clearance measurement. Plasma clearance of 99mTc-MAG3 (ClMAG) was calculated through early renal uptake of 99mTc-MAG3 after appropriate correction of parameters (background, measured attenuation coefficient of 99mTc, and the actual depth of kidneys measured with computed tomography), and on one-compartment assumption of the kinetics of 99mTc-MAG3. We compared the resultant ClMAG with standard effective renal plasma flow (ERPF), using the para-aminohippurate clearance method and with simulated ClMAG derived from the two-compartment model. RESULTS ClMAG calculated by the one-compartment model (283+/-131 ml/min, mean +/- SD) correlated with ERPF (r = 0.94, p <0.001), and was similar to the simulated ClMAG estimated from the two-compartment model in all patients (283+/-139 ml/min). CONCLUSIONS This alternative method, which employs theoretical modeling of the pharmacokinetics of 99mTc-MAG3, may provide easy, noninvasive measurement of individual renal function without blood sampling or in vitro equipment. Further studies should be warranted.

UI MeSH Term Description Entries
D007674 Kidney Diseases Pathological processes of the KIDNEY or its component tissues. Disease, Kidney,Diseases, Kidney,Kidney Disease
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011866 Radioisotope Renography Graphic tracing over a time period of radioactivity measured externally over the kidneys following intravenous injection of a radionuclide which is taken up and excreted by the kidneys. Renography,Radioisotope Renographies,Renographies,Renographies, Radioisotope,Renography, Radioisotope
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015902 Gamma Cameras Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers. Scintillation Cameras,Nuclear Cameras,Scinti-Cameras,Camera, Gamma,Camera, Nuclear,Camera, Scintillation,Cameras, Gamma,Cameras, Nuclear,Cameras, Scintillation,Gamma Camera,Nuclear Camera,Scinti Cameras,Scinti-Camera,Scintillation Camera
D017263 Technetium Tc 99m Mertiatide A technetium diagnostic aid used in renal function determination. 99mTc-MAG3,Tc 99m Mertiatide,Technetium-99m-MAG3,99mTc-Mercaptoacetyltriglycine,TechneScan MAG3,Technetium 99m Mercaptoacetylglycyl-glycyl-glycine,Technetium-99m-Mercaptoacetylglycylglycylglycine,Technetium-99m-Mercaptoacetyltriglycine,99m Mercaptoacetylglycyl-glycyl-glycine, Technetium,99m Mertiatide, Tc,99mTc MAG3,99mTc Mercaptoacetyltriglycine,MAG3, TechneScan,Mercaptoacetylglycyl-glycyl-glycine, Technetium 99m,Mertiatide, Tc 99m,Technetium 99m MAG3,Technetium 99m Mercaptoacetylglycyl glycyl glycine,Technetium 99m Mercaptoacetylglycylglycylglycine,Technetium 99m Mercaptoacetyltriglycine
D017596 Renal Plasma Flow, Effective The amount of PLASMA flowing to the parts of the KIDNEY that function in the production of urine. It is the amount of plasma perfusing the KIDNEY TUBULES per unit time, generally measured by P-AMINOHIPPURATE clearance. It should be differentiated from RENAL PLASMA FLOW which is approximately 10% greater than the effective renal plasma flow. ERPF,Plasma Flow, Renal, Effective,Effective Renal Plasma Flow
D019275 Radiopharmaceuticals Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) Radiopharmaceutical

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