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Little is known about the regulation of catecholamine-stimulated lipolysis in human skeletal muscle. Therefore, beta-adrenergic regulation of lipolysis and blood flow was investigated in healthy subjects in vivo by use of microdialysis of the gastrocnemius muscle. First, during a hypoglycemic, hyperinsulinemic clamp, which induces a lipolytic response in skeletal muscle tissue, the muscle was locally perfused with beta-adrenoceptor blocking agents. Perfusion with nonselective (propranolol) and beta2-selective (ICI-118551) blocking agents counteracted the hypoglycemia-induced lipolysis (P < 0.01), but perfusion with metoprolol (beta1-blocker) did not affect the glycerol response. Second, selective beta-adrenoceptor agonists were perfused in situ into skeletal muscle during resting conditions. beta2-Adrenoceptor stimulation with terbutaline induced a concentration-dependent increase in skeletal muscle glycerol levels and in tissue blood flow, whereas perfusion with beta1- or beta3-adrenoceptor agonists (dobutamine or CGP-12177) did not influence the glycerol concentration or blood flow. In conclusion, in skeletal muscle tissue, only the beta2-subtype is of importance among beta-adrenoceptors for regulation of lipolysis and blood flow. This is in contrast to adipose tissue, where beta1- and beta3-adrenoceptors are also involved.
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
January 1979,
General pharmacology,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
March 2015,
Autonomic neuroscience : basic & clinical,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
February 1964,
Circulation research,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
January 2003,
Advances in experimental medicine and biology,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
August 1964,
Circulation research,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
December 2012,
The Journal of physiology,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
January 1974,
The Journal of clinical investigation,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
March 1996,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
January 1988,
Hormone and metabolic research. Supplement series,
E Hagström-Toft, and
S Enoksson, and
E Moberg, and
J Bolinder, and
P Arner
September 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
