-transparent.png){kind=logo}
Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, 5, and 30 minutes after injection were examined. Uremic and sulfonamide-pretreated rats showed significantly higher levels of 14C in brain and heart and more free thiopental in plasma at each time than did control animals. There was a significant correlation between the free thiopental in plasma and total drug concentrations in the brain and heart. Uremic rats bound less thiopental in plasma compared with controls in spite of normal total plasma protein and albumin concentrations. It is concluded that reduced protein binding of thiopental leads to accelerated distribution and increased drug concentrations in the brain and and heart.
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
December 1970,
Arzneimittel-Forschung,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
June 1988,
Journal of cardiothoracic anesthesia,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
September 2004,
Clinical chemistry,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
April 1993,
Acta anaesthesiologica Scandinavica,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
September 1954,
The Journal of pharmacology and experimental therapeutics,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
January 1995,
Cancer chemotherapy and pharmacology,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
January 1990,
Therapeutic drug monitoring,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
June 2006,
Drug metabolism and disposition: the biological fate of chemicals,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
August 1988,
Journal of neurochemistry,
M M Ghoneim, and
H B Pandya, and
S E Kelley, and
L J Fischer, and
R J Corry
July 1978,
European journal of clinical pharmacology,
