-transparent.png){kind=logo}
The antiviral effect of 9-methylstreptimidone (9-MS) was examined in mice infected with mouse-adapted influenza A(2) (H(2)N(2)) virus. Both a single and continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison between the minimal effective and the 50% lethal dose gave a therapeutic index of 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. After a single intraperitoneal administration of 9-MS, a highly potent virus-inhibitory factor was detected in the lungs (10 h later) and the sera (16 h later) of uninfected mice, which was assumed to be an interferon on the basis of the biological characteristics. These results suggest that the protective activity of the antibiotic is due to interferon induction in mice.
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
March 1974,
The Journal of antibiotics,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
March 1995,
The Journal of antibiotics,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
November 1976,
Helvetica chimica acta,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
September 2011,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
December 1980,
Uirusu,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
January 2012,
Bioorganic & medicinal chemistry letters,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
August 1981,
Antibiotiki,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
January 2006,
Journal of Asian natural products research,
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
June 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
N Saito, and
F Suzuki, and
K Sasaki, and
N Ishida
January 1986,
Voprosy virusologii,
