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Two macrolide antibiotics, josamycin and erythromycin stearate, were administered orally to healthy, adult male volunteers for a comparative study of their pharmacological properties. In comparable doses, josamycin and erythromycin produced similar plasma concentrations, with similar half-lives and elimination constants. An initial loading dose of 1.5 g of josamycin produced greater peak concentrations of antibiotic throughout a 10-day period with a regimen of every 6 h. In addition, josamycin tended to reach higher peak and trough concentrations after regimens of every 6 or 8 h were maintained for 2 days. Josamycin penetrated into saliva, sweat, and tears, and it was better tolerated in fasting subjects than was erythromycin stearate.
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
February 1960,
Antibiotic medicine & clinical therapy (New York, NY),
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
August 1984,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
September 1953,
Antibiotics & chemotherapy (Northfield, Ill.),
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
September 1989,
The Journal of pharmacology and experimental therapeutics,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
September 1988,
International journal of clinical pharmacology, therapy, and toxicology,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
June 1980,
MMW, Munchener medizinische Wochenschrift,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
June 1954,
Journal of the American Medical Association,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
January 1969,
The Journal of the Egyptian Medical Association,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
January 1963,
Bulletin de la Societe francaise de dermatologie et de syphiligraphie,
L J Strausbaugh, and
W K Bolton, and
J A Dilworth, and
R L Guerrant, and
M A Sande
May 1971,
The Medical journal of Australia,
