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In the case of a 48 year old woman with characteristic signs of erythropoetic protoporphyria, a solitary gall-stone which had persisted over a period of 10 years was removed. Porphyrin-concentration of this gall-stone was found to be 22.6 mcg/g, which is almost twenty times the concentration of other cholestrol-stones. Besides protoporphyrin, porphyrins with a higher degree of carboxylation were discovered in four different samples by thin layer chromatography. It is postulated that the increased bile-concentration of protoporphyrin in the liver causes the cristallisation of cholestrol and the formation and growth of gall-stones. The biochemical finding of porphyrins with a higher degree of carboxylation indicates that the porphyrins of the gall-stone may not only come from hemolysed erythrocytes but possibly also from metabolites of disturbed hepatic porphyrin biosynthesis.
G Goerz, and
T Krieg, and
K Bolsen, and
S Seubert, and
H Ippen
January 1977,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
G Goerz, and
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October 1992,
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G Goerz, and
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January 1981,
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July 1973,
Klinische Wochenschrift,
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July 1974,
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G Goerz, and
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January 1977,
Clinica chimica acta; international journal of clinical chemistry,
G Goerz, and
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August 1978,
Leber, Magen, Darm,
G Goerz, and
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October 1978,
Scandinavian journal of clinical and laboratory investigation,
G Goerz, and
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February 1977,
Wiener klinische Wochenschrift,
G Goerz, and
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H Ippen
June 1995,
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