Serum immunoreactive gastrin in rheumatoid arthritis. Further observations on its identity, clinical specificity, and relationship to gastric function. 1976

P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick

Serum immunoreactive gastrin is raised in some patients with rheumatoid arthritis (RA). In this paper paired samples taken within 30 minutes of each other show that this phenomenon is reproducible. Dilution curves show identity between gastrin from RA patients and from patients with no RA, and the raised immunoreactive gastrin concentration is demonstrable in patients who do not have chronic atrophic gastritis and in whom both basal and stimulated acid output concentrations are normal. Samples of gastric mucous membrane obtained from the body of the stomach and gastroscopy under direct vision in 18 patients with raised serum immunoreactive gastrin concentrations were normal.

UI MeSH Term Description Entries
D008297 Male Males
D010418 Pentagastrin A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. Acignost,Gastrin Pentapeptide,Peptavlon,Pentapeptide, Gastrin
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D005260 Female Females
D005750 Gastric Juice The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651) Gastric Juices,Juice, Gastric,Juices, Gastric
D005755 Gastrins A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters. Gastrin
D006632 Histamine An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001172 Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated. Rheumatoid Arthritis

Related Publications

P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
December 1978, Bollettino della Societa italiana di biologia sperimentale,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
April 1979, Annals of the rheumatic diseases,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
February 1976, Annals of the rheumatic diseases,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
June 1982, Revue du rhumatisme et des maladies osteo-articulaires,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
June 1982, Minerva medica,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
March 1975, Surgery,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
January 1968, University of Michigan Medical Center journal,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
January 1973, Nature,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
January 1955, Transactions of the Pacific Coast Oto-Ophthalmological Society annual meeting,
P J Rooney, and A C Kennedy, and G H Gray, and R D Sturrock, and K D Buchanan, and W C Dick
October 1988, Arthritis and rheumatism,
Copied contents to your clipboard!