Biomaterial Database

The effect of difenoxin on the lower esophageal sphincter pressure in man. 1976

B A Bron, and G J Krejs, and P Peter, and A L Blum

Difenoxin, a new antidiarrheal agent, had no effect on lower esophageal sphincter pressure in man when given at an oral dose of 2 mg. Thus, this drug does not appear to cause or aggravate symptoms of gastro-esophageal reflux and may safely be used in reflux patients.

UI	MeSH Term	Description	Entries
D007540	Isonipecotic Acids		Acids, Isonipecotic
D008297	Male		Males
D008365	Manometry	Measurement of the pressure or tension of liquids or gases with a manometer.	Tonometry,Manometries
D010919	Placebos	Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.	Sham Treatment
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D004157	Diphenoxylate	A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.	Diphenoxylate Hydrochloride,Diphenoxylate Monohydrochloride,Hydrochloride, Diphenoxylate,Monohydrochloride, Diphenoxylate
D004943	Esophagogastric Junction	The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.	Gastroesophageal Junction,Gastroesophageal Junctions,Junction, Esophagogastric,Junction, Gastroesophageal,Junctions, Gastroesophageal
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000930	Antidiarrheals	Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.	Antidiarrheal,Antidiarrheal Agent,Antidiarrheal Drug,Antiperistaltic,Antiperistaltics,Antidiarrheal Agents,Antidiarrheal Drugs,Antiperistaltic Agents,Antiperistaltic Drugs,Agent, Antidiarrheal,Agents, Antidiarrheal,Agents, Antiperistaltic,Drug, Antidiarrheal,Drugs, Antidiarrheal,Drugs, Antiperistaltic