The provision of high quality care for people with Motor Neurone Disease (MND) is challenging. The physical and psychological health needs experienced in this progressively disabling disease necessitate input from many disciplines. In order to integrate the delivery of care, the preferred model for MND is a disease-specific team. Such teams can offer a coordinated range of skills, expertise and clinical experience in a setting of interprofessional support. Teams may adopt several formats; multidisciplinary, interdisciplinary and transdisciplinary. In multidisciplinary teams the different professions work to individually set goals and meet to discuss their progress. In interdisciplinary teams goals are first agreed by the team, whose members then coordinate their input to the common treatment plan. In transdisciplinary teams, not only goals but skills are shared. Teamwork allows the coordination of input and the sharing of skills and experience in solving complex clinical problems. Greater flexibility and integration of work make best use of resources. Disease-specific teams act as an educational resource and stimulate awareness of the condition. Teams should undertake clinical research, to strengthen their practice and demonstrate their effectiveness. Effective teamwork, whether in a clinical or research team, requires issues of responsibility, leadership, interprofessional rivalry and communication to be addressed.