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The severity of acute mountain sickness (AMS) was investigated in healthy volunteers, airlifted to high altitude (5,360 m). Blood gases were measured at 2,990 m and 5,360 m. Symptoms of AMS were found in all subjects, but ranged from malaise to vomiting with intractable headache. The clinical severity of AMS was directly related to the arterial PCO2 and inversely to pH, but unrelated to the PO2 on arrival at high altitude. However, PO2 fell and was lowest 48 h after arrival at high altitude in those subjects with the most severe AMS. These were the only subjects to show an increase in the alveolar-arterial PO2 difference and in the venous admixture ratio during the first 48 h. These abnormalities in gas exchange, which developed in the subjects with the most marked cerebral symptoms, suggest that the manifestations of cerebral and pulmonary dysfunction at altitude develop simultaneously, a finding that suggests coexisting cerebral and pulmonary edema.
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
January 2002,
High altitude medicine & biology,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
March 1992,
Annals of internal medicine,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
January 1994,
Ryoikibetsu shokogun shirizu,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
January 1979,
Respiration; international review of thoracic diseases,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
March 1993,
Deutsche medizinische Wochenschrift (1946),
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
October 1993,
Deutsche medizinische Wochenschrift (1946),
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
June 1996,
Journal of the Royal Society of Medicine,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
July 1991,
The Journal of the Association of Physicians of India,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
November 2017,
JAMA,
J R Sutton, and
A C Bryan, and
G W Gray, and
E S Horton, and
A S Rebuck, and
W Woodley, and
I D Rennie, and
C S Houston
January 1969,
The New England journal of medicine,
