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Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins. 1998
A Monge, and
A López de Ceráin, and
O Ezpeleta, and
H Cerecetto, and
E Dias, and
R Di Maio, and
M González, and
S Onetto, and
G Seoane, and
L Suescun, and
R Mariezcurrena
Department of Medicinal Chemistry, University of Navarra, Pamplona, Spain.
Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.
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