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The population pharmacokinetic profile of vancomycin (VCM) in Japanese pediatric patients infected with methicillin-resistant Staphylococcus aureus was analyzed using 181 samples of serum concentration data from 49 patients obtained in routine drug monitoring. The one-compartment linear model was adopted, where the VCM clearance (CL) and the distribution volume (Vd) were correlated with covariates such as postnatal age (AGE) and body weight (BWT). The population pharmacokinetic analysis program NONMEM with the first-order conditional estimation method was used. The results showed that the population mean clearance normalized by BWT increases with AGE up to 1 year of age [CL(L/hour per kg) = 0.1 19 + 0.0619 x (AGE - 1)] and decreases with age over 1 year old [CL(L/hour per kg) = 0.119 + 0.00508 x (1 - AGE)]. The population mean of the distribution volume normalized by BWT was independent of AGE (Vd (L/kg) = 0.522). The interindividual variability of CL was 39.6%, and that of Vd was 18.8%. The intraindividual, residual variability was 34.6%. These results were compared with those in other articles, and a guideline for dosage adjustment in VCM therapy is discussed.
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
June 2017,
International journal of clinical pharmacology and therapeutics,
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
January 2019,
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG,
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
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M Yasuhara, and
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H Zenda, and
K Okumura, and
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Y Yano, and
R Hori
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M Yasuhara, and
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R Hori
October 2018,
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
August 2020,
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
January 2012,
TheScientificWorldJournal,
M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
August 2023,
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M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
October 2000,
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M Yasuhara, and
T Iga, and
H Zenda, and
K Okumura, and
T Oguma, and
Y Yano, and
R Hori
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