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Mutagenicity of microcystin-LR in human RSa cells. 1998
H Suzuki, and
M F Watanabe, and
Y Wu, and
T Sugita, and
K Kita, and
T Sato, and
X Wang, and
H Tanzawa, and
S Sekiya, and
N Suzuki
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku-ku, Tokyo 169-0073, Japan.
Microcystin-LR (MCLR) is a potent cyclic heptapeptidic hepatotoxin produced by bloom-forming cyanobacteria. The mutagenicity induced by this compound in cultured human RSa cells was found by determination of ouabain-resistant (OuaR) mutation, with the highest frequency at the concentration of 15 microgram/ml. Moreover, base substitution mutations at K-ras codon 12 in genomic DNA, assessed by polymerase chain reaction (PCR) and differential dot-blot hybridization using digoxigenin-labeled probes, were detected in RSa cells 6 days after exposure to MCLR (7.5-15 microgram/ml).
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