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1. Glycoprotein synthesis was investigated with [1-14C]glucosamine in vivo. [14C]Glucosamine was administered intravenously 24h after hepatectomy to rats. 2. Incorporation into the acid-soluble fraction was maximum at 15 min after injection both in sham-operated and hepatectomized rats. 3. Enhancement of incorporation into UDP-N-acetylhexosamine in regenerating liver was observed. However, its specific activity was lower, because of a greater enhancement of synthesis de novo of the amino sugar. 4. In the liver acid-insoluble fraction, maximum incorporation of [14C]glucosamine was at 30 min in sham-operated rats and 2 h in hepatectomized rats respectively. 5. In sham-operated rats, incorporation into the plasma acid-insoluble fraction followed that of the liver acid-insoluble fraction, but hepatectomy resulted in a rapid enchancement of incorporation into plasma. 6. It is concluded that synthesis of liver glycoproteins is stimulated after partial hepatectomy and that glycoproteins synthesized are released rapidly into the plasma.
N Akamatsu, and
H Nakajima, and
S Miyata
July 1979,
Cancer research,
N Akamatsu, and
H Nakajima, and
S Miyata
August 1971,
Biochimica et biophysica acta,
N Akamatsu, and
H Nakajima, and
S Miyata
January 1976,
The Biochemical journal,
N Akamatsu, and
H Nakajima, and
S Miyata
July 1970,
Endocrinology,
N Akamatsu, and
H Nakajima, and
S Miyata
September 1981,
Cancer letters,
N Akamatsu, and
H Nakajima, and
S Miyata
July 1956,
Cancer research,
N Akamatsu, and
H Nakajima, and
S Miyata
September 1980,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
N Akamatsu, and
H Nakajima, and
S Miyata
December 1985,
The American journal of physiology,
N Akamatsu, and
H Nakajima, and
S Miyata
June 1980,
The Biochemical journal,
N Akamatsu, and
H Nakajima, and
S Miyata
January 1977,
Osaka city medical journal,
