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Alterations of hypothalamic neuropeptide Y(NPY) and melanocortinergic functions in diet-induced obese (DIO) C57BL/6J mice were investigated by in situ hybridization. Compared with controls, the DIO mice displayed a profound induction (approximately 40-fold) of NPY expression in the dorsomedial (DMH) and ventromedial (VMH) hypothalamic nuclei, whereas the level of NPY mRNA in the arcuate nucleus (ARC) was reduced by 44%. The expression of pro-opiomelanocortin (POMC) and agouti-related protein was not significantly altered in the ARC of obese mice. Both excess body weight gain and altered hypothalamic NPY expression were reversible. We propose that the highly induced NPY expression in DMH and/or VMH may be a contributing etiological factor for the development of obesity and leptin resistance in the DIO mice.
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
September 2013,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
June 2009,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
January 2016,
American journal of physiology. Regulatory, integrative and comparative physiology,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
January 2019,
Acta endocrinologica (Bucharest, Romania : 2005),
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
January 1994,
Peptides,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
June 2004,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
December 2019,
Neuro endocrinology letters,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
June 2013,
Obesity (Silver Spring, Md.),
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
November 2018,
Neuroscience letters,
X M Guan, and
H Yu, and
M Trumbauer, and
E Frazier, and
L H Van der Ploeg, and
H Chen
August 2006,
Life sciences,
