-transparent.png){kind=logo}
Various gag mutants of human immunodeficiency virus type 1 (HIV-1) generated in vitro were evaluated for their potentials to suppress the replication of wild-type (wt) virus. A single-round of wt virus replication in the presence of various mutant proteins was quantitatively monitored by transfection and infection experiments. Out of 38 mutants examined, 15 were demonstrated to interfere with the replication of wt HIV-1 at early and/or late viral replication phase. Some of these mutants were also effective against the replication of wt HIV-2. In this review, we focus on the mutants, which are able to act against a wide variety of HIV, and are very useful for future gene therapy against AIDS.
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
December 2000,
AIDS research and human retroviruses,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
June 1999,
Nature medicine,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
August 1995,
Journal of virology,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
October 2002,
Microbes and infection,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
April 1996,
The Journal of biological chemistry,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
March 2009,
Retrovirology,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
December 2008,
Immunity,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
January 1997,
Drugs under experimental and clinical research,
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
March 2007,
Science (New York, N.Y.),
R Inubushi, and
R Shimano, and
Y Oshima, and
K Yoshida, and
M Kawamura, and
A Adachi
May 1999,
Gene therapy,
