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Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
January 2008,
PloS one,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
September 1996,
Science (New York, N.Y.),
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
August 1996,
Cell,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
February 1999,
Cellular and molecular life sciences : CMLS,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
April 1999,
Current biology : CB,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
December 1995,
The EMBO journal,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
August 1996,
Cell,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
February 2006,
Molecular and cellular biology,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
May 2015,
Molecular and cellular biology,
D Hermand, and
A Pihlak, and
T Westerling, and
V Damagnez, and
J Vandenhaute, and
G Cottarel, and
T P Mäkelä
May 2006,
Cell cycle (Georgetown, Tex.),
