Biomaterial Database

Hemoglobin-oxygen-carbon monoxide equilibria with the MWC model. 1998

N M Senozan, and J A DeVore, and E K Lesniewski

Department of Chemistry and Biochemistry, California State University, Long Beach 90840, USA.

Fractional saturation equations for the Monod, Wyman and Changeux model are derived for the case of two distinct ligands bonding to a host molecule with four ligand sites and two conformational states. A variety of useful graphical studies can be derived from these equations when applied to normal human hemoglobin with O2 and CO as ligands. For example, the oxygen transport capability of hemoglobin can be assessed at different environmental CO levels and the concentrations of various liganded species can be displayed as a function of fractional saturation with oxygen. In addition, the CO pressure in the tissue, PCOtissue, can be calculated as a function of the tissue oxygen pressure, PO2tissue, at different environmental levels of CO. In an environment of a given CO concentration, PCOtissue decreases with PO2tissue until a minimum is reached. Further decrease in PO2tissue results in a fairly steep rise in PCOtissue.

UI	MeSH Term	Description	Entries
D008956	Models, Chemical	Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.	Chemical Models,Chemical Model,Model, Chemical
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D002248	Carbon Monoxide	Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)	Monoxide, Carbon
D006454	Hemoglobins	The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.	Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man