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To clarify the role of thrombopoietin (c-Mpl ligand, TPO) in 'hypersplenic' thrombocytopenia, we used an enzyme-linked immunosorbent assay to examine changes in serum TPO levels accompanied with splenectomy in 6 patients with liver cirrhosis, 4 patients with gastric cancer, and 2 patients with lymphoid malignancies. We also measured serum levels of other thrombopoietic cytokines such as interleukin-6 (IL-6) and erythropoietin. Platelet counts reached a maximum at day 14 after splenectomy in all subjects. In patients with liver cirrhosis, a lower elevation of platelet counts was observed compared with that in patients with gastric cancer. Serum TPO levels gradually elevated after splenectomy and reached a maximum 3.5 days after splenectomy in noncirrhotic patients, whereas peak serum TPO levels were delayed until day 7 in the cirrhosis group. IL-6 and erythropoietin showed similar kinetics between cirrhotic and noncirrhotic patients. These findings suggest that transient thrombocytosis after splenectomy may be associated with an alteration in the site of TPO catabolism by platelets from spleen to the blood and that deterioration of TPO production may play a role in thrombocytopenia in liver cirrhosis.
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
September 1999,
British journal of haematology,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
September 1978,
American journal of surgery,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
January 1993,
Journal of investigational allergology & clinical immunology,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
June 1996,
Blood,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
February 1998,
British journal of haematology,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
February 1970,
Archives of disease in childhood,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
January 1989,
Acta chirurgica Iugoslavica,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
January 2002,
Lupus,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
January 2001,
Pflugers Archiv : European journal of physiology,
N Ichikawa, and
K Kitano, and
S Shimodaira, and
F Ishida, and
T Ito, and
S Kajikawa, and
T Tahara, and
T Kato, and
K Kiyosawa
January 1984,
American journal of diseases of children (1960),
