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A GC-MS method for the investigation on the metabolism of 6-methoxy n-butyl phthalide (MBP) is described. After oral administration of MBP, the rat urine sample was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. MBP and its six oxidative metabolites were determined in the 0-24 h rat urine sample. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
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