BIOMAT Database Logo BIOMAT Database Logo

Interferon-delta: the first member of a novel type I interferon family. 1998

F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Unité de Virologie et Immunologie Moléculaires, Inra, Jouy-En-Josas, France.

We have recently described a novel type I interferon (IFN) co-expressed with IFN-gamma by the trophectoderm of the pig conceptus between day 12 and day 18 of gestation, a development stage that corresponds to implantation in the uterus. This IFN, now officially named IFN-delta, is recognized as the first member of a novel type I IFN family. This paper reviews the main published data on IFN-delta, together with some new data, showing that IFN-delta, while being a true type I IFN, has some very specific structural and biological properties. Sequences related to IFN-delta coding sequence were found in the genome of man and other ungulates but the only other potentially functional gene was found, so far, in the horse. The pig IFN-delta mature protein, with 149 amino acids, is the smallest of all known type I IFNs. It is unusually rich in cysteines (seven residues), and has a very basic isoelectric point. Recombinant IFN-delta expressed in insect cells is glycosylated and has a high antiviral activity on porcine cells, but not on human cells. It has high antiproliferative activity, which is significantly enhanced in the presence of IFN-gamma. This new IFN was shown to bind on pig cells to the same type I receptor as IFN-alpha. IFN-delta and IFN-gamma genes are co-regulated in the pig trophectoderm, whose cells on day 14-16 of development simultaneously secrete both IFN proteins. The biological role of porcine IFN-delta in early pregnancy has been found unrelated to the known antiluteolytic effect of trophoblastic IFN-tau in ruminants.

UI MeSH Term Description Entries
D007370 Interferon Type I Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). Interferons Type I,Type I Interferon,Type I Interferons,Interferon, Type I,Interferons, Type I
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D017471 Receptors, Interferon Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system. Interferon Receptors,Interferon Receptor,Receptor, Interferon
D018507 Gene Expression Regulation, Developmental Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. Developmental Gene Expression Regulation,Embryologic Gene Expression Regulation,Gene Expression Regulation, Embryologic,Regulation of Gene Expression, Developmental,Regulation of Gene Expression, Embryologic,Regulation, Gene Expression, Developmental,Regulation, Gene Expression, Embryologic

Related Publications

F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Human interferon-lambda3 is a potent member of the type III interferon family.
March 2009, Genes and immunity,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8.
November 2001, Journal of dental research,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
A Novel Type-I Interferon Family, Bovine Interferon-Chi, Is Involved in Positive-Feedback Regulation of Interferon Production.
January 2020, Frontiers in immunology,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
The receptor of the type I interferon family.
January 2007, Current topics in microbiology and immunology,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Capitella sp. I homeobrain-like, the first lophotrochozoan member of a novel paired-like homeobox gene family.
October 2006, Gene expression patterns : GEP,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Restrictin-P: the first member of a putative family of novel inhibitors.
January 1991, Annals of the New York Academy of Sciences,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
How unique is interferon-β within the type I interferon family?
November 2018, Cytokine,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.
March 1994, Cell,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
EcoA: the first member of a new family of type I restriction modification systems. Gene organization and enzymatic activities.
November 1985, Journal of molecular biology,
F Lefèvre, and M Guillomot, and S D'Andréa, and S Battegay, and C La Bonnardière
Interferon-kappa, a novel type I interferon expressed in human keratinocytes.
October 2001, The Journal of biological chemistry,
Copied contents to your clipboard!