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The circuits that control movement are comprised of discrete subtypes of motor neurons. How motor neuron subclasses develop and extend axons to their correct targets is still poorly understood. We show that LIM homeodomain factors Lhx3 and Lhx4 are expressed transiently in motor neurons whose axons emerge ventrally from the neural tube (v-MN). Motor neurons develop in embryos deficient in both Lhx3 and Lhx4, but v-MN cells switch their subclass identity to become motor neurons that extend axons dorsally from the neural tube (d-MN). Conversely, the misexpression of Lhx3 in dorsal-exiting motor neurons is sufficient to reorient their axonal projections ventrally. Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube.
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
February 2007,
Molecular and cellular endocrinology,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
January 1999,
Molecular and cellular endocrinology,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
December 2000,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
July 2017,
Scientific reports,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
January 2009,
Pediatric endocrinology reviews : PER,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
January 2005,
Journal of cellular biochemistry,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
May 2008,
Developmental dynamics : an official publication of the American Association of Anatomists,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
February 2008,
Biochemical and biophysical research communications,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
January 2012,
PloS one,
K Sharma, and
H Z Sheng, and
K Lettieri, and
H Li, and
A Karavanov, and
S Potter, and
H Westphal, and
S L Pfaff
November 2004,
Endocrinology,
