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A new indole derivative from the red alga Chondria atropurpurea. Isolation, structure determination, and anthelmintic activity. 1998
D Davyt, and
W Entz, and
R Fernandez, and
R Mariezcurrena, and
A W Mombrú, and
J Saldaña, and
L Domínguez, and
J Coll, and
E Manta
Facultad de Química, Universidad de la República, Av. Gral. Flores, 2124 Montevideo, Uruguay.
Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, 3-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N1,N1'-trimethyl derivative of compound 2) against Nippostrongylus brasiliensis in vitro were evaluated.
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