The adhesion molecule in the vascular endothelial cell is outlined, we reports on our result about the relation etc. among the adhesion molecule, the acute myocardial infarction, and the insulin resistance, and utility as the clinical examination is described the time. This study measured the serum concentrations of circulating adhesion molecules by sandwich enzyme-linked immunosorbent assay with the acute myocardial infarction (AMI) and the insulin resistance, and the expression of adhesion molecules on lymphocyte were analyzed by flow-cytometry. Only ELAM level in AMI disease were significantly higher (p < 0.01) than controls. sELAM has the possibility of the foresight marker of the AMI diagnosis. The correlation of SSPG value of index of the insulin resistance and IL-6, sELAM-1, and sICAM-1 takes part in condition when the immune reaction through cytokine and the adhesion molecule administered insulin. The relation between insulin and the adhesion molecule was suggested from the result of using the vascular endothelial cell. Endothelial cells are stimulated dramatically and increase the appearance of adhesion molecules on surface of the cell by the interactions with leukocytes. In these interactions with AMI and the insulin resistance, ELAM, ICAM-1 and VCAM-1 are suggested to play the most important role.