-transparent.png){kind=logo}
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist. 1998
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.
Related Publications
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
October 1998,
Brain research. Molecular brain research,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
May 1996,
The Journal of pharmacology and experimental therapeutics,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
December 1999,
Bioorganic & medicinal chemistry letters,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
June 1996,
European journal of pharmacology,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
December 2007,
Bioorganic & medicinal chemistry letters,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
August 2002,
Journal of medicinal chemistry,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
January 1992,
Journal of medicinal chemistry,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
January 2006,
Xenobiotica; the fate of foreign compounds in biological systems,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
August 2000,
Bioorganic & medicinal chemistry letters,
T J Rosen, and
K J Coffman, and
S McLean, and
R T Crawford, and
D K Bryce, and
Y Gohda, and
M Tsuchiya, and
A Nagahisa, and
M Nakane, and
J A Lowe
April 1987,
Journal of medicinal chemistry,
