-transparent.png){kind=logo}
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
Related Publications
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
January 2005,
The Journal of biological chemistry,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
October 2017,
Biochemistry. Biokhimiia,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
January 2024,
Methods in molecular biology (Clifton, N.J.),
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
April 2010,
Critical reviews in biochemistry and molecular biology,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
June 1984,
European journal of biochemistry,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
November 1977,
The Journal of biological chemistry,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
December 2004,
Protein expression and purification,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
September 2008,
Biochemistry,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
January 2021,
Frontiers in plant science,
M Tandon, and
M Wu, and
T P Begley, and
J Myllyharju, and
A Pirskanen, and
K Kivirikko
October 2012,
Blood,
