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High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. 1998
Department of Medicinal Chemistry, Merck Sharp Laboratory, Essex, U.K. timothy_harrison@merck.com
High affinity, selective hNK2 or hNK3 ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK3 ligands 3 antagonise the calcium mobilisation caused by activation of hNK3 receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.
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