Biomaterial Database

Determination of 6s-trans conformation of retinal chromophore in sensory rhodopsin I and phoborhodopsin. 1998

A Wada, and A Akai, and T Goshima, and T Takahashi, and M Ito

Kobe Pharmaceutical University, Japan.

8,16-Ethanoretinal 3 was synthesized from 2-methylcyclohexanone. From the binding experiments of 3 and 8,18-ethanoretinal 2 with apoproteins of sensory rhodopsin I and phoborhodopsin, it was found that retinal was incorporated as 6s-trans conformation in the both proteins.

UI	MeSH Term	Description	Entries
D002338	Carotenoids	The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons containing 4 terpene subunits.	Carotenes,Carotenoid,Tetraterpene Derivatives,Tetraterpenes,Carotene,Derivatives, Tetraterpene
D006217	Halobacterium	A genus of HALOBACTERIACEAE whose growth requires a high concentration of salt. Binary fission is by constriction.
D001436	Bacteriorhodopsins	Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.	Bacteriorhodopsin
D012172	Retinaldehyde	A diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.	11-trans-Retinal,3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal,Axerophthal,Retinal,Retinene,Retinyl Aldehydde,Vitamin A Aldehyde,all-trans-Retinal,11-cis-Retinal,11 cis Retinal,11 trans Retinal,Aldehydde, Retinyl,Aldehyde, Vitamin A,all trans Retinal
D013237	Stereoisomerism	The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D019843	Archaeal Proteins	Proteins found in any species of archaeon.	Archaeal Gene Products,Archaeal Gene Proteins,Archaeal Peptides,Gene Products, Archaeal,Gene Proteins, Archaeal
D025602	Halorhodopsins	Light driven chloride ion pumps that are ubiquitously found in halophilic archaea (HALOBACTERIALES).	Halorhodopsin,9-cis-Halorhodopsin,Halorhodopsin Chromoprotein,9 cis Halorhodopsin
D025603	Sensory Rhodopsins	Photosensory rhodopsins found in microorganisms such as HALOBACTERIA. They convert light signals into biochemical information that regulates certain cellular functions such as flagellar motor activity.	Sensory Rhodopsin,Rhodopsin, Sensory,Rhodopsins, Sensory