-transparent.png){kind=logo}
We sought to clarify the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) during healing of rat gastric ulcers. After gastric ulcers were induced by acetic acid, rats were treated with vehicle, N(G)-nitro-L-arginine methyl ester (L-NAME), aminoguanidine (AG), and dexamethasone (Dex) by gastric intubation twice a day for 3 days to 1 week. L-NAME significantly delayed healing compared with vehicle. AG and Dex significantly reduced ulcer size 3 days after ulcer induction but did not further reduce ulcer size 1 week after induction. iNOS expression was present in inflammatory cells, some epithelial cells, and in vascular smooth muscle in the regenerating mucosa of the vehicle-treated group. However, the number of iNOS-positive inflammatory cells increased in the AG- and L-NAME-treated groups. AG and L-NAME significantly increased the number of inflammatory cells with endogenous peroxidase and significantly reduced the number of apoptotic inflammatory cells compared with vehicle. In conclusion, inhibition of iNOS increases the number of inflammatory cells in the ulcer margin and delays ulcer healing. These observations suggest that NO generated from iNOS not only participates in ulcer formation but also plays a beneficial role in ulcer healing, in part by the exclusion of iNOS-positive inflammatory cells from the regenerating mucosa.
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
August 1993,
European journal of pharmacology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
January 1999,
The American journal of physiology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
September 1997,
Anesthesiology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
August 2000,
American journal of physiology. Gastrointestinal and liver physiology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
March 2001,
Journal of medical microbiology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
November 1994,
The Journal of pharmacology and experimental therapeutics,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
February 2017,
Bone & joint research,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
September 1998,
Current opinion in drug discovery & development,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
May 2004,
The Journal of urology,
Y Akiba, and
M Nakamura, and
M Mori, and
H Suzuki, and
M Oda, and
H Kimura, and
S Miura, and
M Tsuchiya, and
H Ishii
January 1999,
The Journal of biological chemistry,
