BIOMAT Database Logo BIOMAT Database Logo

Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS). 1998

M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Department of Biomedical Sciences, University of Rhode Island, Kingston 02881-0809, USA.

Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.

UI MeSH Term Description Entries
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D000225 Adenine A purine base and a fundamental unit of ADENINE NUCLEOTIDES. Vitamin B 4,4, Vitamin B,B 4, Vitamin
D058892 Adenosine Deaminase Inhibitors Drugs that inhibit ADENOSINE DEAMINASE activity. ADA Inhibitors,Deaminase Inhibitors, Adenosine,Inhibitors, ADA,Inhibitors, Adenosine Deaminase

Related Publications

M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Adenosine deaminase inhibitors. Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine.
October 1994, Journal of medicinal chemistry,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Inhibitors of adenosine deaminase.
January 1982, Pharmacology & therapeutics,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.
September 2001, Bioorganic & medicinal chemistry letters,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.
August 2004, Bioorganic & medicinal chemistry letters,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
July 1999, Bioorganic & medicinal chemistry letters,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Specificity of adenosine deaminase inhibitors.
November 1977, Biochemical pharmacology,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Adenosine deaminase inhibitors: differential effects on multiple forms of adenosine deaminase.
November 1978, Biochemical and biophysical research communications,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation.
October 1993, Journal of medicinal chemistry,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.
October 1992, Journal of medicinal chemistry,
M A Curtis, and V Varkhedkar, and P V Pragnacharyulu, and E Abushanab
Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
February 1988, Journal of medicinal chemistry,
Copied contents to your clipboard!