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A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives. 1998
R Saladino, and
M C Danti, and
E Mincione, and
C Crestini, and
A T Palamara, and
P Savini, and
S Marini, and
M Botta
Dipartimento Agrochimico Agrobiologico, Università degli studi di Viterbo La Tuscia, Italy. Saladino@unitus.it
Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication.
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