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Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents. 1998
Q Li, and
W Wang, and
K B Berst, and
A Claiborne, and
L Hasvold, and
K Raye, and
M Tufano, and
A Nilius, and
L L Shen, and
R Flamm, and
J Alder, and
K Marsh, and
D Crowell, and
D T Chu, and
J J Plattner
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
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