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Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2. 1998
J Milton, and
M J Slater, and
A J Bird, and
D Spinks, and
G Scott, and
C E Price, and
S Downing, and
D V Green, and
S Madar, and
R Bethell, and
D K Stammers
Department of Chemistry, GlaxoWellcome Medicines Research Center, Stevenage, Oxford.
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50S in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
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G Scott, and
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D V Green, and
S Madar, and
R Bethell, and
D K Stammers
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Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy,
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D V Green, and
S Madar, and
R Bethell, and
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September 2006,
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