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Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4-trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones. 1998
H Fukui, and
T Shibata, and
T Naito, and
J Nakano, and
T Maejima, and
H Senda, and
W Iwatani, and
Y Tatsumi, and
M Suda, and
T Arika
Central Research Institute, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R, 4S)-3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphylococcus aureus and low side effect potential.
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