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Hydroindenic-guanylhydrazones. Synthesis and evaluation as inotropic agents. 1998
C P Melero, and
L G Sevillano, and
E Caballero, and
F Tomé, and
R Carrón, and
M J Montero, and
A San Feliciano, and
M Medarde
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
The synthesis and inotropic activity of two families of hydroindenic compounds are described. Among them, a bis-guanylhydrazone derivative has demonstrated to produce an interesting positive inotropic effect on guinea pig atria, displaying at higher dosis a similar effect to that elicited by digoxin.
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