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Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. 1998
M Macchia, and
F Salvetti, and
S Barontini, and
F Calvani, and
M Gesi, and
M Hamdan, and
A Lucacchini, and
A Pellegrini, and
P Soldani, and
C Martini
GlaxoWellcome Medicines Research Center, Verona, Italy. mmacchia@farm.unipi.it
New fluorescent ligands for adenosine receptors are described; these compounds were obtained by the insertion, in the N6 position of NECA (a potent adenosine agonist), of dansylaminoalkyl moieties with alkyl spacers of increasing carbon chain length (from 3 to 12). Among them, the compound with a C6 alkyl spacer proved to be the most interesting one, showing a marked selectivity for the A1 receptor subtype; furthermore, in fluorescence microscopy assays it proved to be able to visualize and localize this receptor subtype at the level of the molecular layer of the rate cerebellar cortex.
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