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The incidence of leptomeningeal carcinomatosis is on the rise and current treatment modalities have limited efficacy. The development of new treatment strategies has been hampered by the lack of an appropriate animal model that accurately parallels the clinical condition. We have developed a new surgical technique for the establishment of leptomeningeal tumors in rats. Our technique is simple, reproducible and associated with low morbidity and mortality. Tumor implantation resulted in a defined neurological endpoint and a reproducible time course of disease progression using both human medulloblastoma and breast carcinoma cell lines. This animal model provides an appropriate system for testing conventional and new biologic therapies in both early and late stages of leptomeningeal disease.
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
August 2013,
Musculoskeletal surgery,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
January 1998,
Annales de chirurgie,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
October 1982,
The British journal of dermatology,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
February 1979,
The Journal of laboratory and clinical medicine,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
September 1979,
Australian veterinary journal,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
December 1994,
British journal of urology,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
January 1981,
European journal of orthodontics,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
September 2013,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
October 1984,
Anesthesiology,
K H Janczewski, and
C L Chalk, and
R B Pyles, and
L M Parysek, and
L W Unger, and
R E Warnick
January 1990,
Archives roumaines de pathologie experimentales et de microbiologie,
