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Regulation of multifunctional Ca2+/calmodulin-dependent protein kinases by Ca2+/calmodulin-dependent protein kinase phosphatase. 1998

A Ishida, and S Okuno, and T Kitani, and I Kameshita, and H Fujisawa
Department of Biochemistry, Asahikawa Medical College, Japan.

We have recently reported a novel protein phosphatase which dephosphorylates and thereby deactivates Ca2+/calmodulin-dependent protein kinase II (CaMKII) activated through autophosphorylation (Ishida, A., Kameshita, I., and Fujisawa, H. (1998) J. Biol. Chem. 273, 1904-1910). In the present study, we show that this protein phosphatase also catalyzed dephosphorylation of Ca2+/calmodulin-dependent protein kinases I (CaMKI) and IV (CaMKIV) which had been phosphorylated and activated by Ca2+/calmodulin-dependent protein kinase kinase alpha, resulting in reversible deactivation of the enzymes. The fairly high degree of the substrate specificity of this protein phosphatase suggests that the physiological significance of the phosphatase may be the regulation of the three multifunctional Ca2+/calmodulin-dependent protein kinases, CaMKI, CaMKII, and CaMKIV, which are the key enzymes in a Ca(2+)-signaling system in the cell.

UI MeSH Term Description Entries
D009097 Multienzyme Complexes Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES. Complexes, Multienzyme
D010749 Phosphoprotein Phosphatases A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992) Phosphoprotein Phosphatase,Phosphoprotein Phosphohydrolase,Protein Phosphatase,Protein Phosphatases,Casein Phosphatase,Ecto-Phosphoprotein Phosphatase,Nuclear Protein Phosphatase,Phosphohistone Phosphatase,Phosphoprotein Phosphatase-2C,Phosphoseryl-Protein Phosphatase,Protein Phosphatase C,Protein Phosphatase C-I,Protein Phosphatase C-II,Protein Phosphatase H-II,Protein-Serine-Threonine Phosphatase,Protein-Threonine Phosphatase,Serine-Threonine Phosphatase,Threonine Phosphatase,Ecto Phosphoprotein Phosphatase,Phosphatase C, Protein,Phosphatase C-I, Protein,Phosphatase C-II, Protein,Phosphatase H-II, Protein,Phosphatase, Casein,Phosphatase, Ecto-Phosphoprotein,Phosphatase, Nuclear Protein,Phosphatase, Phosphohistone,Phosphatase, Phosphoprotein,Phosphatase, Phosphoseryl-Protein,Phosphatase, Protein,Phosphatase, Protein-Serine-Threonine,Phosphatase, Protein-Threonine,Phosphatase, Serine-Threonine,Phosphatase, Threonine,Phosphatase-2C, Phosphoprotein,Phosphatases, Phosphoprotein,Phosphatases, Protein,Phosphohydrolase, Phosphoprotein,Phosphoprotein Phosphatase 2C,Phosphoseryl Protein Phosphatase,Protein Phosphatase C I,Protein Phosphatase C II,Protein Phosphatase H II,Protein Phosphatase, Nuclear,Protein Serine Threonine Phosphatase,Protein Threonine Phosphatase,Serine Threonine Phosphatase
D001933 Brain Stem The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA. Brainstem,Truncus Cerebri,Brain Stems,Brainstems,Cerebri, Truncus,Cerebrus, Truncus,Truncus Cerebrus
D004789 Enzyme Activation Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme. Activation, Enzyme,Activations, Enzyme,Enzyme Activations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013379 Substrate Specificity A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. Specificities, Substrate,Specificity, Substrate,Substrate Specificities
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054729 Calcium-Calmodulin-Dependent Protein Kinase Type 1 A monomeric calcium-calmodulin-dependent protein kinase subtype that is expressed in a broad variety of mammalian cell types. Its expression is regulated by the action of CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. Several isoforms of this enzyme subtype are encoded by distinct genes. CaM Kinase I,CaM Kinase I alpha,CaM Kinase I beta,CaM Kinase I delta,CaM Kinase I gamma,CaMK-Like CREB Kinase III,Calcium-Calmodulin-Dependent Protein Kinase Type 1 alpha Isoform,Calcium-Calmodulin-Dependent Protein Kinase Type 1 beta Isoform,Calcium-Calmodulin-Dependent Protein Kinase Type 1 delta Isoform,Calcium-Calmodulin-Dependent Protein Kinase Type 1 gamma Isoform,Calcium-Calmodulin-Dependent Protein Kinase Type 1A,Calcium-Calmodulin-Dependent Protein Kinase Type 1B,Calcium-Calmodulin-Dependent Protein Kinase Type 1D,Calcium-Calmodulin-Dependent Protein Kinase Type 1G,Calcium-Calmodulin-Dependent Protein Kinase Type 1alpha,Calcium-Calmodulin-Dependent Protein Kinase Type 1beta,Calcium-Calmodulin-Dependent Protein Kinase Type 1delta,Calcium-Calmodulin-Dependent Protein Kinase Type 1gamma,Calcium-Dependent CaM Kinase I,Calmodulin-Dependent Protein Kinase I,CamKI-Like Protein Kinase,Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase,CaMK Like CREB Kinase III,Calcium Calmodulin Dependent Protein Kinase Type 1,Calcium Calmodulin Dependent Protein Kinase Type 1 alpha Isoform,Calcium Calmodulin Dependent Protein Kinase Type 1 beta Isoform,Calcium Calmodulin Dependent Protein Kinase Type 1 delta Isoform,Calcium Calmodulin Dependent Protein Kinase Type 1 gamma Isoform,Calcium Calmodulin Dependent Protein Kinase Type 1A,Calcium Calmodulin Dependent Protein Kinase Type 1B,Calcium Calmodulin Dependent Protein Kinase Type 1D,Calcium Calmodulin Dependent Protein Kinase Type 1G,Calcium Calmodulin Dependent Protein Kinase Type 1alpha,Calcium Calmodulin Dependent Protein Kinase Type 1beta,Calcium Calmodulin Dependent Protein Kinase Type 1delta,Calcium Calmodulin Dependent Protein Kinase Type 1gamma,Calcium Dependent CaM Kinase I,Calmodulin Dependent Protein Kinase I,CamKI Like Protein Kinase,Pregnancy Upregulated Non Ubiquitously Expressed CaM Kinase,Protein Kinase, CamKI-Like
D054732 Calcium-Calmodulin-Dependent Protein Kinase Type 2 A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. Ca(2+)-Calmodulin Dependent Protein Kinase Type II,CaCMKII,CaM KII,CaM KIIalpha,CaM KIIbeta,CaM KIIdelta,CaM Kinase II,CaM Kinase II alpha,CaM Kinase II beta,CaM Kinase II delta,CaM Kinase II gamma,CaM PK II,CaM-Kinase II,CaM-Kinase IIalpha,CaMKII,CaMKIIgamma,Calcium-Calmodulin Dependent Protein Kinase II beta,Calcium-Calmodulin Dependent Protein Kinase II delta,Calcium-Calmodulin Dependent Protein Kinase II gamma,Calcium-Calmodulin Protein Kinase II,Calcium-Calmodulin-Dependent PK Type II,Calcium-Calmodulin-Dependent Protein Kinase Type 2 alpha Subunit,Calcium-Calmodulin-Dependent Protein Kinase Type 2 beta Subunit,Calcium-Calmodulin-Dependent Protein Kinase Type 2 delta Subunit,Calcium-Calmodulin-Dependent Protein Kinase Type 2 gamma Subunit,Calcium-Dependent CaM Kinase II,Calmodulin Kinase IIalpha,Calmodulin-Dependent Protein Kinase II,CaM Kinase IIalpha,Calcium Calmodulin Dependent PK Type II,Calcium Calmodulin Dependent Protein Kinase II beta,Calcium Calmodulin Dependent Protein Kinase II delta,Calcium Calmodulin Dependent Protein Kinase II gamma,Calcium Calmodulin Dependent Protein Kinase Type 2,Calcium Calmodulin Dependent Protein Kinase Type 2 alpha Subunit,Calcium Calmodulin Dependent Protein Kinase Type 2 beta Subunit,Calcium Calmodulin Dependent Protein Kinase Type 2 delta Subunit,Calcium Calmodulin Dependent Protein Kinase Type 2 gamma Subunit,Calcium Calmodulin Protein Kinase II,Calcium Dependent CaM Kinase II,Calmodulin Dependent Protein Kinase II
D054734 Calcium-Calmodulin-Dependent Protein Kinase Type 4 A monomeric calcium-calmodulin-dependent protein kinase subtype that is primarily expressed in neuronal tissues; T-LYMPHOCYTES and TESTIS. The activity of this enzyme is regulated by its phosphorylation by CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. Calmodulin-Dependent Protein Kinase IV,CaM Kinase IV,Calcium-Calmodulin-Dependent Protein Kinase IV,Camk-4,Neuronal CaM Kinase Gr,Calcium Calmodulin Dependent Protein Kinase IV,Calcium Calmodulin Dependent Protein Kinase Type 4,Calmodulin Dependent Protein Kinase IV

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