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The renal concentrating ability was studied in ten patients with hypothyroidism and in 15 euthyroid controls. Solute-free water reabsorption was reduced in the patients with myxedema (4.2 +/- 0.3 ml/min: controls 5.8 +/- 0.6 ml/min; p less than 0.01). This defect was apparent at high rates of solute excretion, and was associated with enhanced excretion of sodium (p less than 0.01) despite a decreased filtered load (p less than 0.005). The myxedema patients had a modest reduction in maximal urine osmolality (p less than 0.04), which was entirely attributable to the lower values observed in younger patients. The results may be explained best by decreased sodium chloride reabsorption in the ascending limb of Henle's loop and/or diminished permeability of the distal nephron in myxedema.
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
May 1983,
Archives of surgery (Chicago, Ill. : 1960),
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
March 1975,
The Journal of laboratory and clinical medicine,
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
March 2007,
Acta physiologica (Oxford, England),
C A Vaamonde, and
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E L Klingler, and
S Papper
October 1958,
The Journal of clinical endocrinology and metabolism,
C A Vaamonde, and
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S Papper
December 2000,
Laboratory investigation; a journal of technical methods and pathology,
C A Vaamonde, and
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L S Vaamonde, and
E L Klingler, and
S Papper
February 1979,
British medical journal,
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
March 1979,
British medical journal,
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
March 1979,
British medical journal,
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
December 1966,
The Yale journal of biology and medicine,
C A Vaamonde, and
U F Michael, and
J R Oster, and
M J Sebastianelli, and
L S Vaamonde, and
E L Klingler, and
S Papper
December 2002,
Nephron,
