BIOMAT Database Logo BIOMAT Database Logo

Evaluation of guar gum in the preparation of sustained-release matrix tablets. 1998

P Khullar, and R K Khar, and S P Agarwal
Dabur Research Foundation, Ghaziabad, India.

Polymeric hydrophilic matrices are widely used for controlled-release preparations. The process of drug release is controlled by matrix swelling or polymer dissolution. It has been shown that the swelling of guar gum is affected by concentration of drug and viscosity grade of the polymer. This study examines the mechanism of behavior of guar gum in a polymer-drug matrix. The swelling action of guar gum, in turn, is controlled by the rate of water uptake into the matrices. An inverse relationship exists between the drug concentration in the gel and matrix swelling. This implies that guar gum swelling is one of the factors affecting drug release. The swelling behavior of guar gum is therefore useful in predicting drug release.

UI MeSH Term Description Entries
D008351 Mannans Polysaccharides consisting of mannose units. Mannan
D002626 Chemistry, Pharmaceutical Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use. Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D003692 Delayed-Action Preparations Dosage forms of a drug that act over a period of time by controlled-release processes or technology. Controlled Release Formulation,Controlled-Release Formulation,Controlled-Release Preparation,Delayed-Action Preparation,Depot Preparation,Depot Preparations,Extended Release Formulation,Extended Release Preparation,Prolonged-Action Preparation,Prolonged-Action Preparations,Sustained Release Formulation,Sustained-Release Preparation,Sustained-Release Preparations,Timed-Release Preparation,Timed-Release Preparations,Controlled-Release Formulations,Controlled-Release Preparations,Extended Release Formulations,Extended Release Preparations,Slow Release Formulation,Sustained Release Formulations,Controlled Release Formulations,Controlled Release Preparation,Controlled Release Preparations,Delayed Action Preparation,Delayed Action Preparations,Formulation, Controlled Release,Formulations, Controlled Release,Prolonged Action Preparation,Release Formulation, Controlled,Release Formulations, Controlled,Sustained Release Preparation,Timed Release Preparation,Timed Release Preparations
D005079 Excipients Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc. Excipient,Stabilizing Agent,Stabilizing Agents,Suspending Agent,Suspending Agents,Agent, Stabilizing,Agent, Suspending,Agents, Stabilizing,Agents, Suspending
D005685 Galactans Polysaccharides composed of repeating galactose units. They can consist of branched or unbranched chains in any linkages. Galactan,Polygalactose,Polygalactoses
D005782 Gels Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001702 Biopharmaceutics The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action. Pharmaceutics,Pharmaceutic
D013607 Tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed) Tablet
D013806 Theophylline A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. 1,3-Dimethylxanthine,3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione,Accurbron,Aerobin,Aerolate,Afonilum Retard,Aquaphyllin,Armophylline,Bronchoparat,Bronkodyl,Constant-T,Elixophyllin,Euphylong,Glycine Theophyllinate,Lodrane,Monospan,Nuelin,Nuelin S.A.,Quibron T-SR,Slo-Phyllin,Somophyllin-T,Sustaire,Synophylate,Theo Von Ct,Theo-24,Theo-Dur,Theobid,Theocin,Theoconfin Continuous,Theodur,Theolair,Theolix,Theon,Theonite,Theopek,Theophylline Anhydrous,Theophylline Sodium Glycinate,Theospan,Theostat,Theovent,Uniphyl,Uniphyllin,Uniphylline,1,3 Dimethylxanthine,Anhydrous, Theophylline,Constant T,ConstantT,Ct, Theo Von,Glycinate, Theophylline Sodium,Quibron T SR,Quibron TSR,Slo Phyllin,SloPhyllin,Sodium Glycinate, Theophylline,Somophyllin T,SomophyllinT,Theo 24,Theo Dur,Theo24,Theophyllinate, Glycine,Von Ct, Theo

Related Publications

P Khullar, and R K Khar, and S P Agarwal
Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets.
March 2007, Drug development and industrial pharmacy,
P Khullar, and R K Khar, and S P Agarwal
Guar gum-based sustained release diltiazem.
August 1998, Pharmaceutical research,
P Khullar, and R K Khar, and S P Agarwal
Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets.
October 2009, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society,
P Khullar, and R K Khar, and S P Agarwal
Blend of guar gum and Eudragit shows excellent drug release retarding behavior in sustained release tablets.
January 2020, Pakistan journal of pharmaceutical sciences,
P Khullar, and R K Khar, and S P Agarwal
Preparation and evaluation of novel metronidazole sustained release and floating matrix tablets.
August 2011, Pharmaceutical development and technology,
P Khullar, and R K Khar, and S P Agarwal
Formulation and in vitro evaluation of sustained release matrix tablets using cross-linked natural gum.
March 2017, Pakistan journal of pharmaceutical sciences,
P Khullar, and R K Khar, and S P Agarwal
Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release.
January 2006, Drug development and industrial pharmacy,
P Khullar, and R K Khar, and S P Agarwal
Formulation and Evaluation of Cola acuminata Gum-based Mucoadhesive Sustained-release Matrix Tablets of Diclofenac Sodium.
January 2023, Recent advances in drug delivery and formulation,
P Khullar, and R K Khar, and S P Agarwal
A contribution to the preparation of matrix-type sustained release tablets.
January 1968, Dansk tidsskrift for farmaci,
P Khullar, and R K Khar, and S P Agarwal
In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride.
July 2005, AAPS PharmSciTech,
Copied contents to your clipboard!