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Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein. 1998
J E Crowe, and
C Y Firestone, and
R Crim, and
J A Beeler, and
K L Coelingh, and
C F Barbas, and
D R Burton, and
R M Chanock, and
B R Murphy
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0720, USA. james.e.crowe@vanderbilt.edu
A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.
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