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To elucidate the mechanism of action of various antioxidants, we studied the kinetics of chemiluminescence which accompanies the peroxidation of phospholipid liposomes as induced by divalent iron ions in the presence of C-525, a chemiluminescence activator. EDTA and desferal reduced the chemiluminescence latent period, probably, due to the chelation of Fe2+ ions which, thus, dropped out of chain oxidation reactions in the lipid phase. In contrast, ascorbate increased the chemiluminescence latent period, apparently, as a result of regeneration of divalent iron oxidized during lipid peroxidation. alpha-Tocopherol and rutin reduced the amplitude of the chemiluminescence slow flash and increased the duration of the latent period. beta-Carotene displayed its effect only at rather high concentrations, when the decrease in chemiluminescence intensity could be due (at least partially) to the reabsorption of chemiluminescence by this compound. The latent period remained invariable in this case.
O V Vasiljeva, and
O B Lyubitsky, and
G I Klebanov, and
Vladimirov YuA
January 1991,
Ophthalmic research,
O V Vasiljeva, and
O B Lyubitsky, and
G I Klebanov, and
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January 1995,
Biological trace element research,
O V Vasiljeva, and
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February 2000,
Phytotherapy research : PTR,
O V Vasiljeva, and
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February 1984,
Lipids,
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Vladimirov YuA
January 2001,
Radiatsionnaia biologiia, radioecologiia,
O V Vasiljeva, and
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January 1983,
Farmakologiia i toksikologiia,
O V Vasiljeva, and
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G I Klebanov, and
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June 1991,
Die Pharmazie,
O V Vasiljeva, and
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G I Klebanov, and
Vladimirov YuA
January 2000,
Indian journal of physiology and pharmacology,
O V Vasiljeva, and
O B Lyubitsky, and
G I Klebanov, and
Vladimirov YuA
October 1994,
Redox report : communications in free radical research,
O V Vasiljeva, and
O B Lyubitsky, and
G I Klebanov, and
Vladimirov YuA
August 1979,
Indian journal of biochemistry & biophysics,
