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The stimulation of isolated chicken embryo chondrocytes was studied by measuring the incorporation of [3H]uridine and [3H]leucine into cold trichloroacetic acid precipitable material after exposure of the chondrocytes to serum. The doseresponse relationships for the incorporation of uridine and leucine were similar to that of thymidine previously demonstrated. Exposure of the cells to serum-containing buffer for 15 min sufficed both for the stimulation of incorporation into the cells and for the depletion of 28% of the stimulating activity from the medium. Stimulation persisted for at least 17 h after removal of the serum. Studies where actinomycin D was added to inhibit RNA synthesis suggested that prior RNA synthesis was required for most of the stimulation of protein synthesis by serum factors.
J T Garland, and
F Buchanan
February 1969,
Life sciences,
J T Garland, and
F Buchanan
April 1972,
Endocrinology,
J T Garland, and
F Buchanan
September 1987,
Infection and immunity,
J T Garland, and
F Buchanan
April 1988,
Science (New York, N.Y.),
J T Garland, and
F Buchanan
May 1978,
Metabolism: clinical and experimental,
J T Garland, and
F Buchanan
May 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J T Garland, and
F Buchanan
August 1972,
Proceedings of the National Academy of Sciences of the United States of America,
J T Garland, and
F Buchanan
February 1981,
Biochemistry,
J T Garland, and
F Buchanan
January 1980,
Placenta,
J T Garland, and
F Buchanan
October 1969,
General and comparative endocrinology,
