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The effect of an anti-microbial protein, calprotectin, in combination with neutrophils on the growth of Candida albicans was investigated. The growth inhibition of C. albicans by murine neutrophils was augmented by the addition of a low concentration of calprotectin prepared from rat peritoneal exudate cells. The concentrations of calprotectin causing 50% inhibition of growth of C. albicans in the absence or presence of neutrophils at an effector-to-target (E/T) ratio of 30 and 60 were estimated to be 0.45, 0.34 and 0.28 U/ml, respectively. The anti-Candida activity of calprotectin was completely inhibited by 2 microM of zinc ion, while it only partially lowered the activity of the combination of calprotectin and neutrophils. Lactoferrin, which is an anti-microbial protein released from neutrophils, strongly inhibited the growth of C. albicans in combination with calprotectin. These results suggest that calprotectin and lactoferrin released from neutrophils may cooperate to inhibit the growth of C. albicans at a local lesion of the infection where there is an accumulation of neutrophils.
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
January 1996,
Microbiology and immunology,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
January 1998,
Advances in experimental medicine and biology,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
January 2016,
Digestive diseases (Basel, Switzerland),
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
January 1998,
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
October 2008,
Inflammatory bowel diseases,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
October 2004,
Phytotherapy research : PTR,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
August 2019,
Future microbiology,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
June 2009,
The British journal of surgery,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
October 2010,
Inflammatory bowel diseases,
T Okutomi, and
T Tanaka, and
S Yui, and
M Mikami, and
M Yamazaki, and
S Abe, and
H Yamaguchi
June 2012,
Gastroenterology clinics of North America,
