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1. In Wistar rats pretreated with factor XIII, placebo (human albumin solution), or physiological saline, a muscle wound was produced. For pre- and postlabelling purposes the animals received 3H-thymidine. 2. Autoradiographic and histological examinations revealed wound healing promoting activity of factor XIII from 72 h post operationem onwards. 3. 7 days after surgery, in contrast to the controls, the animals pretreated with factor XIII displayed sturdy, directed connective tissue in the wound bed with ample vascularization. 4. The method with pre- and postlabelling with 3H-thymidine elucidates that wound healing through factor XIII prevailingly occurs by faster fibroblast formation.
H Knoche, and
G Schmitt
December 1977,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Knoche, and
G Schmitt
April 1979,
Wiener klinische Wochenschrift,
H Knoche, and
G Schmitt
January 1974,
Langenbecks Archiv fur Chirurgie,
H Knoche, and
G Schmitt
May 1974,
Deutsche medizinische Wochenschrift (1946),
H Knoche, and
G Schmitt
August 1967,
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
H Knoche, and
G Schmitt
January 1980,
Zentralblatt fur Chirurgie,
H Knoche, and
G Schmitt
May 1974,
MMW, Munchener medizinische Wochenschrift,
H Knoche, and
G Schmitt
January 1974,
Langenbecks Archiv fur Chirurgie,
H Knoche, and
G Schmitt
November 1968,
Arzneimittel-Forschung,
