BIOMAT Database Logo BIOMAT Database Logo

CT imaging of intrathoracic lymph nodes in dogs with bronchoscopically administered iodinated nanoparticles. 1999

L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA.

OBJECTIVE The purpose of the study was to determine if airway instillation of iodinated nanoparticles results in contrast material enhancement of tracheobronchial lymph nodes in dogs. METHODS Eight dogs underwent intrabronchial instillation of iodinated nanoparticles; six dogs received 900 mg each, and two dogs received 450 mg each. Spiral computed tomography (CT) was then performed 2-34 days later. RESULTS CT scans obtained 2 days after instillation showed the presence of contrast material within the lung parenchyma but no nodal enhancement. Scans obtained 6-34 days after instillation showed enhancement of the right, left, and middle tracheobronchial lymph nodes (analogous to the mediastinal nodes in humans). Mean nodal attenuation on CT images was 117 HU +/- 43, and the mean nodal volume was 129 mm3 +/- 113. Histologic specimens of the nodes showed macrophage hyperplasia. CONCLUSIONS Iodinated nanoparticles instilled into small airways are transported to the tracheobronchial lymph nodes, where they result in contrast enhancement.

UI MeSH Term Description Entries
D006965 Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. Hyperplasias
D007455 Iodine A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically. Iodine-127,Iodine 127
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D011856 Radiographic Image Enhancement Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed. Digital Radiography,Image Enhancement, Radiographic,Radiography, Digital,Enhancement, Radiographic Image,Enhancements, Radiographic Image,Image Enhancements, Radiographic,Radiographic Image Enhancements
D001995 Bronchography Radiography of the bronchial tree after injection of a contrast medium. Bronchographies
D001999 Bronchoscopy Endoscopic examination, therapy or surgery of the bronchi. Bronchoscopic Surgical Procedures,Surgical Procedures, Bronchoscopic,Bronchoscopic Surgery,Surgery, Bronchoscopic,Bronchoscopic Surgeries,Bronchoscopic Surgical Procedure,Bronchoscopies,Surgeries, Bronchoscopic,Surgical Procedure, Bronchoscopic

Related Publications

L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Pulmonary delivery of nanoparticles of insoluble, iodinated CT X-ray contrast agents to lung draining lymph nodes in dogs.
November 1998, Journal of pharmaceutical sciences,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Indirect computed tomography lymphography of subdiaphragmatic lymph nodes using iodinated nanoparticles in normal dogs.
May 1995, Academic radiology,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
CT appearance of presumptively normal intrathoracic lymph nodes in cats.
October 2020, Journal of feline medicine and surgery,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Iodinated nanoparticles for indirect computed tomography lymphography of the craniocervical and thoracic lymph nodes in normal dogs.
December 1994, Academic radiology,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Giant intrathoracic lymph nodes.
February 1959, The Journal of thoracic surgery,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Intrathoracic lymph flow, with special regard to the communication of intrathoracic lymph vessels with cervical lymph nodes.
December 1965, The Kumamoto medical journal,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Endobronchial Ultrasound Multimodal Imaging for the Diagnosis of Intrathoracic Lymph Nodes.
January 2021, Respiration; international review of thoracic diseases,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Magnetic resonance imaging of the lymph nodes: comparison with CT.
December 1984, Radiology,
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
[Angiofollicular hyperplasia of intrathoracic lymph nodes].
January 1975, Grudnaia khirurgiia (Moscow, Russia),
L H Ketai, and B A Muggenberg, and G L McIntire, and E R Bacon, and R Rosenberg, and P E Losco, and J L Toner, and K J Nikula, and P Haley
Contrast-enhancement properties of irradiated normal lymph nodes: initial experience with interstitially delivered iodinated nanoparticles.
April 1998, Academic radiology,
Copied contents to your clipboard!